Nefro - 24-1 MIOLO.indd
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چکیده
Minimal change nephropathy (MCN) is characterised by the development of nephrotic syndrome in the absence of histological changes on light microscopy or immune complex deposition on immunofluorescence. Ultrastructural examination typically reveals diffuse epithelial foot process effacement. In children under 10 MCN accounts for up to 90% of those presenting with the nephrotic syndrome1. Paediatric nephrologists, therefore, reserve renal biopsy for patients with atypical clinical features or those who fail to respond to first line treatment. MCN becomes progressively less common as a cause of nephrotic syndrome through adolescence. In adults, 10 -30% of those with nephrotic syndrome are subsequently shown to have MCN2;3. In our own centre, which serves a population of around one million individuals, 173 patients have had a renal biopsy after developing nephrotic syndrome in the last six years. In this population of adult patients MCN was the third commonest diagnosis (13%) after focal and segmental glomerulosclerosis (FSGS) (15%) and membranous nephropathy (34%). PATHOGENESIS
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تاریخ انتشار 2010